Bridging Themes: Short Protein Segments Found in Different Architectures

Bridging the gap between enterprise architectures and software architectures

The US Federal Agencies’ Chief Information Officer Council in its guide to Federal Enterprise Architecture has defined an Enterprise Architecture (EA) to be “a strategic information asset base, which defines the mission, the information necessary to perform the mission and the technologies necessary to perform the mission, and the transitional processes for implementing new technologies in resp...

Primes in Short Segments of Arithmetic Progressions

Λ is the von Mangoldt function, and ∑ * a(q) denotes a sum over a set of reduced residues modulo q. We shall assume throughout x ≥ 2, 1 ≤ q ≤ x, 1 ≤ h ≤ x, (1.3) the other ranges being without interest. As far as we are aware the only known result concerning the general function I(x, h, q) is due to Prachar [11], who showed that, assuming the Generalized Riemann Hypothesis (GRH) I(x, h, q) ≪ hx...

Short protein segments can drive a non-fibrillizing protein into the amyloid state.

Protein fibrils termed amyloid-like are associated with numerous degenerative diseases as well as some normal cellular functions. Specific short segments of amyloid-forming proteins have been shown to form fibrils themselves. However, it has not been shown in general that these segments are capable of driving a protein from its native structure into the amyloid state. We applied the 3D profile ...

Are They Found in Different Therapies?

Bridging Dichotomies in Cognitive Architectures for Virtual Humans

Desiderata for cognitive architectures that are to support the extent of human-level intelligence required in virtual humans imply the need to bridge a range of dichotomies faced by such architectures. The focus here is first on two general approaches to building such bridges – addition and reduction – and then on a pair of general tools – graphical models and piecewise continuous functions – t...